Work

Mechanisms of Human Immunodeficiency Virus-Associated Lymphocyte Regulated Cell Death

Year: 2019

Type: review

Abstract: Human immunodeficiency virus-1 (HIV-1) causes CD4 T cell depletion through a number of mechanisms, including programmed cell death pathways (both apoptotic and nonapoptotic). In the setting of HIV-1 infection, the enhanced lymphocyte cell death occurs as a consequence of complex interactions between the host immune system and viral factors, which are reviewed herein. On the other hand, the main challenge to HIV-1 eradication is the development of latent infection in a subset of long lived cells, including CD4+ T cells and macrophages, which resist HIV-induced cell death. Understanding the potential mechanisms of how HIV-1 induces lymphocyte cell death is critical to the “kick and kill” cure strategy, which relies on the effective killing of reactivated, HIV-1-infected cells.

Source: AIDS Research and Human Retroviruses

DOI: 10.1089/aid.2019.0213

Authors: Ana C. Paim, Andrew D. Badley, Nathan W. Cummins

Institution: Mayo Clinic

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases