Work

Amphetamine Use in the Elderly: A Systematic Review of the Literature

Year: 2019

Type: review

Abstract: OBJECTIVE: To systematically review the literature on the therapeutic use of amphetamine, lisdexamfetamine and methylphenidate in elderly population with and without dementia. METHODS: We conducted two researches on the PubMed, Scopus and Embase using the keywords ("elderly") AND ("amphetamine" OR "methylphenidate" OR "lisdexamfetamine") and then ("Alzheimer" OR "dementia") AND ("amphetamine" OR "methylphenidate" OR "lisdexamfetamine"). RESULTS: Twenty-nine papers met all the eligibility criteria. The results are encouraging as 81.5% of the studies showed clinical improvement of the investigated condition. CONCLUSION: Amphetamines and methylphenidate are probably effective strategies for different conditions in the elderly population. However, further studies are needed to provide more robust evidence on efficacy, dosage and safety for this population.

Source: Current Neuropharmacology

DOI: 10.2174/1570159x17666191010093021

Authors: Karina Lúcia Moreira Sassi, Natalia Pessoa Rocha, Gabriela Delevati Colpo, Vineeth John, Antonio Lucio Teixeira

Institution: The University of Texas Health Science Center at Houston

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2982360720

FWCI: 0.464

Cites: 73

Cited by: 27

Related to: 10