Year: 2019
Type: letter
Abstract: The genes in the human leukocyte antigen (HLA) (human major histocompatibility complex [MHC]) complex are iconic examples of balancing selection (1⇓–3). Two important HLA signatures, the retention of alleles, polymorphism, and haplotypes over evolutionary time, known as transspecies polymorphism, and dN/dS > 1 and the related high polymorphism at functionally important amino acids sites, are fundamental aspects of HLA variation. Using simulation, Lobkovsky et al. (4) examined the causes of variation at the highly variable HLA loci in a large database. However, their results are not consistent with either transspecies polymorphism because of the short observed life of haplotypes or dN/dS > 1 because of the low expected amount of …
[↵][1]1To whom correspondence may be addressed. Email: philip.hedrick{at}asu.edu.
[1]: #xref-corresp-1-1
Authors: Philip W. Hedrick, William Klitz
Institutions: Arizona State University, University of California, Berkeley
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2982533215