Work

Renal Clearable Ru-based Coordination Polymer Nanodots for Photoacoustic Imaging Guided Cancer Therapy

Year: 2019

Type: article

Abstract: Rationale: Despite the promises of applying theranostic nanoagents for imaging-guided cancer therapy, the chronic retention of these nanoagents may cause safety concerns that hinder their future clinical applications.The metabolizable nanoagents with rapid renal excretion to avoid long-term toxicity is a possible solution for this issue.Method: Herein, we synthesize ultra-small metal-organic coordination polymer nanodots based on ruthenium ion (Ru 3+ ) / phenanthroline (Phen) (Ru-Phen CPNs) with superior near-infrared (NIR) absorption.The size, photothermal conversion, cytotoxicity, photoacoustic imaging, in vivo & in vitro cancer treatment efficiency and biosafety are tested.Results: The size of the ultra-small Ru-Phen CPNs is 6.5 nm.The photothermal conversion efficiency is measured to be ~ 60.69 %, much higher than that of previously reported photothermal agents.The Ru-Phen CPNs could be employed for photoacoustic (PA, 808 nm) imaging-guided photothermal therapy (PTT, 808 nm, 0.5 W/cm 2 ) with great performance.Notably, the intrinsic PA signals (808 nm) of Ru-Phen CPNs are observed in kidneys of treated mice, illustrating efficient renal clearance of those ultra-small CPNs.Moreover, the clearance of CPNs is further confirmed by detecting Ru levels in urine and feces.Conclusion: Our work presents a new type of ultra-small Ru-based CPNs with a record high photothermal conversion efficiency, efficient tumor retention after systemic administration, and rapid renal excretion to avoid long-term toxicity, promising for imaging-guided photothermal therapy.

Source: Theranostics

DOI: 10.7150/thno.36986