Work

Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy

Year: 2019

Type: article

Abstract: T lymphocytes caused by defective mitochondrial turnover by autophagy, which may trigger chronic inflammation and contribute to the impairment of immune defense in older persons.

Source: Aging

DOI: 10.18632/aging.102438

Authors: Arsun Bektas, Shepherd H. Schurman, Marta Gonzalez-Freire, Christopher A. Dunn, Amit K. Singh, Fernando Macian, Ana Maria Cuervo, Ranjan Sen, Luigi Ferrucci

Institutions: National Institutes of Health, National Institute on Aging, National Institute of Environmental Health Sciences, Albert Einstein College of Medicine

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Johns Hopkins University, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Environmental Health Sciences

Awards: Autophagy in aging: testing geroscience in Alzheimer's disease, Einstein's Nathan Shock Center of Excellence in Basic Biology of Aging

OpenAlex ID: W2982745597

FWCI: 3.545

Cites: 53

Cited by: 120

Related to: 10