Work

Mechanism of GPER promoting proliferation, migration and invasion of triple-negative breast cancer cells through CAF.

Year: 2019

Type: article

Abstract: expression in CAF, thereby inducing the decrease of cell proliferation, arrest of S phase and suppression of migration and invasion of MDA-MB-231 cells, while GPER agonist could be resulted in the opposite effects. In conclusion, the present data demonstrated that GPER promoted proliferation, migration and invasion of TNBC cells through CAF. Furthermore, GPER expression was positively related to the prognosis of TNBC.

Source: PubMed

Authors: Kaihua Yang, Yufeng Yao

Institutions: Wuxi Fourth People's Hospital, Jiangsu Cancer Hospital, Nanjing Medical University

Language: English

Topic: Estrogen and related hormone effects

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2982785641

FWCI: 1.24

Cites: 28

Cited by: 20

Related to: 10