Expression profile of circular RNA s in TMJ osteoarthritis synovial tissues and potential functions of hsa_circ_0000448 with specific back-spliced junction.
Year: 2019
Type: article
Abstract: OBJECTIVE: As essential players in the occurrence and development of osteoarthritis, circular RNAs (circRNAs) have gradually received attention in recent years. However, their roles in temporomandibular joint osteoarthritis (TMJOA) featured with pain, restricted mouth opening and joint movement dysfunction, remains elusive. METHODS: The expression profile of circRNAs in TMJ synovial tissues was analyzed by RNA-Seq. The differentially expressed circRNAs in the TMJOA were identified. The potential biological functions of these circRNAs were evaluated. RESULTS: experiments. Among them, the up-regulated hsa_circ_0000448 with specific back-splice junction was involved in the TNF-α signaling pathway through CeRNA mechanism by targeting related microRNAs. Additionally, it was also predicted to bind several RNA binding proteins (RBPs), but almost had no protein-coding ability. CONCLUSION: circRNAs in TMJ synovial tissue participate in the progression of TMJOA and may become a potential therapeutic target. The highly up-regulated has_circ_0000448 probably promotes TNF-α secretion of synovium through CeRNA mechanism in TMJOA.
Source: PubMed
Authors: Yihui Hu, Huimin Zhu, Lingtong Bu, Dongmei He
Language: English
Topic: Circular RNAs in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2983093034