Work

Author response: Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance

Year: 2017

Type: peer-review

Abstract: Systematic analyses of natural variants and artificial mutants establish functional landscapes of BRCA1 for homology-directed repair (HDR) and therapy resistance and identify the BRCA1-PALB2 interaction as a key control point for HDR pathway choice.

DOI: 10.7554/elife.21350.019

Authors: Rachel W Anantha, Srilatha Simhadri, Tzeh Keong Foo, Susanna Miao, Jingmei Liu, Zhiyuan Shen, Shridar Ganesan, Bing Xia

Institutions: Rutgers, The State University of New Jersey, Rutgers Cancer Institute

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W2983108619

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