Depletion of CTCF induces craniofacial malformations in mouse embryos.
Year: 2019
Type: article
Abstract: mutant mice. The expression level of chondrogenic and osteogenic-related genes were significantly decreased. Our results implicate CTCF in two distinct events in craniofacial development; first, in the regulation of outgrowth and morphogenesis by cell survival and proliferation, and second, in the differentiation of the facial skeleton. Our findings highlight the important contribution of CTCF to craniofacial pathologies.
Source: PubMed Central
Authors: Hyehyun Min, Hyoung-Pyo Kim, Jeong-Oh Shin
Institutions: Yonsei University, Yonsei University Health System
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2983178259