Effects of sitagliptin on coronary atherosclerosis in patients with type 2 diabetes-A serial integrated backscatter-intravascular ultrasound study.
Year: 2016
Type: article
Abstract: , P = 0.04) was observed on IB-IVUS analysis. Univariate and multivariate regression analyses showed that the percentage change in serum non-high-density lipoprotein (HDL) cholesterol level was an independent and significant predictor of a reduction in lipid plaque volume (β = 0.445, P = 0.04). In conclusions, sitagliptin did not significantly reduce coronary plaque volume in patients with type 2 diabetes. However, a decrease in the lipid plaque volume was observed in the sitagliptin group. A decrease in non-HDL cholesterol level was associated with a reduction in the lipid volume of coronary artery plaques.
Source: PubMed
Institutions: Yokohama Sakae Kyosai Hospital, Kanagawa Cardiovascular and Respiratory Center, Tokyo Kamata Medical Center, Yokohama Minami Kyosai Hospital, Teikyo University Hospital, Mizonokuchi, Teikyo University, Yokosuka Kyosai Hospital, Yokohama City University Medical Center, Yokohama City University Hospital
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2983183310