Year: 2019
Type: article
Study design: Case Report
Abstract: We describe a case of acute liver failure and myopericarditis due to herpes simplex virus-1 (HSV-1) in an immunocompetent adult. We estimate that, at the height of viremia, the patient contained a quantity of HSV-1 virions approaching that of human cells. The patient recovered with acyclovir that was dose-adjusted for neurotoxicity and developed a vigorous anti-HSV-1 T-cell response.
Source: Open Forum Infectious Diseases
DOI: 10.1093/ofid/ofz465
Authors: Kevin Ikuta, Pavitra Roychoudhury, Hong Xie, Christopher L Mcclurkan, Magdalena Walkiewicz, Negar Makhsous, Meei-Li Huang, Yodit Beru, Mariam Alam, Amanda Shepherd, Eric D Lamotte, Kevin Patel, Amy Morris, Başak Ҫoruh, Lei Yu, Renuka Bhattacharya, Rex Cheng, Roland B Walter, Ajit P Limaye, Christina M Lockwood, Steven M Holland, Robert M Rakita, David M Koelle, Alexander L Greninger
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,053
Award: G172982731
OpenAlex ID: W2983395096