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The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences

Year: 2019
Type: article
Abstract: Lymphatic vessels mediate fluid flows that affect antigen distribution and delivery, lymph node stromal remodeling, and cell-cell interactions, to thus regulate immune activation. Here we review the functional role of lymphatic transport and lymph node biomechanics in immunity. We present experimental tools that enable quantitative analysis of lymphatic transport and lymph node dynamics in vitro and in vivo. Finally, we discuss the current understanding for how changes in lymphatic transport and lymph node biomechanics contribute to pathogenesis of conditions including cancer, aging, neurodegeneration, and infection.
Source: iScience
DOI: 10.1016/j.isci.2019.11.005
Institutions: Georgia Institute of Technology, Emory University, The Wallace H. Coulter Department of Biomedical Engineering, Oregon Health & Science University, OHSU Knight Cancer Institute, Winship Cancer Institute
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,000
Funders: American Cancer Society, Cancer Research Institute, National Institutes of Health, Winship Cancer Institute, National Cancer Institute, National Institute of General Medical Sciences, Congressionally Directed Medical Research Programs
Awards: Cell and Tissue Engineering Training Program, G2648405518, G500973873, G678580786, Mechanisms of impaired T-cell mechanosensing of melanoma antigens, G7836371709
OpenAlex ID: W2983464379
FWCI: 2.175
Cites: 159
Cited by: 52
Related to: 10