Work

Inhibition of HIF-1α by PX-478 suppresses tumor growth of esophageal squamous cell cancer in vitro and in vivo.

Year: 2017

Type: article

Abstract: treatment, but inhibited by HIF-1α knock-down or PX-478 treatment. Furthermore, PX-478 significantly inhibited tumor cell proliferation by inhibiting the G2/M transition and promoting apoptosis of ESCC cells. In addition, inhibited epithelial-mesenchymal transition was observed after PX-478 treatment. In vivo, PX-478 significantly decreased tumor volume following subcutaneous implantation. Together, our results indicated that PX-478 had significant antitumor activity against HIF-1α over-expressing ESCC tumors in vitro and in vivo. These results opened up the possibility of inhibiting HIF-1α for targeted therapy of ESCC.

Source: Europe PMC (PubMed Central)

Authors: Yingming Zhu, Yuanwei Zang, Fen Zhao, Zhenxiang Li, Jianbo Zhang, Liang Fang, Minghuan Li, Ligang Xing, Zhonghua Xu, Jinming Yu

Institutions: Shandong University, Shandong Tumor Hospital, Qilu Hospital of Shandong University

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2983614336

FWCI: 1.573

Cites: 36

Cited by: 44

Related to: 10