Work

Author response: Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in S. pombe

Year: 2017

Type: peer-review

Abstract: Mutation of Glycine 34 to Arginine within the N-terminal tail of histone H3 alters post-translational modifications on Lysine 36 and is associated with a delay in replication restart, defective homologous recombination and an increase in genomic instability.

DOI: 10.7554/elife.27406.025

Authors: Rajesh K Yadav, Carolyn M Jablonowski, Alfonso G Fernandez, Brandon R Lowe, Ryan A Henry, David Finkelstein, Kevin J Barnum, Alison L Pidoux, Yin-Ming Kuo, Jie Huang, Matthew J O’Connell, Andrew J Andrews, Arzu Onar-Thomas, Robin C Allshire, Janet F Partridge

Institutions: St. Jude Children's Research Hospital, Fox Chase Cancer Center, Icahn School of Medicine at Mount Sinai, University of Edinburgh

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

OpenAlex ID: W2983807501

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