Work

Author response: Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

Year: 2017

Type: peer-review

Abstract: Cell culture models widely used in cancer research do not reflect metabolism in tumors; by altering culture systems to better model tumor metabolism we find that environmental cystine promotes tumor glutamine metabolism.

Source: eLife

DOI: 10.7554/elife.27713.032

Authors: Alexander Muir, Laura V Danai, Dan Y Gui, Chiara Y Waingarten, Caroline A Lewis, Matthew G Vander Heiden

Institutions: Koch Institute for Integrative Cancer Research At MIT, Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

OpenAlex ID: W2983821751

Cites:

Cited by: 4

Related to: 10