Work

Chromosome Territorial Organization Drives Efficient Protein Complex Formation: A Hypothesis.

Year: 2019

Type: article

Abstract: In eukaryotes, chromosomes often form a transcriptional kissing loop during interphase. We propose that these kissing loops facilitate the formation of protein complexes. mRNA transcripts from these loops could cluster together into phase-separated nuclear granules. Their export into the ER could be ensured by guided diffusion through the inter-chromatin space followed by association with nuclear baskets and export factors. Inside the ER, these mRNAs would form a translation hub. Juxtaposed translation of these mRNAs would increase the cis/trans protein complex assembly among the nascent protein chains. Eukaryotes might employ this pathway to increase complex formation efficiency.

Source: Europe PMC (PubMed Central)

Authors: Manindra Bera, Ramalingam Venkat Kalyana Sundaram

Institution: Yale University

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Regulation of Membrane Fusion in Exocytosis, Mechanisms of Intracellular Membrane Fusion

OpenAlex ID: W2983939138

FWCI: 0.073

Cites: 87

Cited by: 1

Related to: 10