Work

Author response: Structure-based inhibitors of amyloid beta core suggest a common interface with tau

Year: 2019

Type: peer-review

Abstract: Aβ inhibitors effectively block its aggregation, while also reducing seeding of tau aggregation from Aβ, tau, and AD derived fibrils, suggesting the two share a structurally related disease relevant interface.

Source: eLife

DOI: 10.7554/elife.46924.036

Authors: Sarah L Griner, Paul Seidler, Jeannette Bowler, Kevin A Murray, Tianxiao Peter Yang, Shruti Sahay, Michael R Sawaya, Duilio Cascio, Jose A Rodriguez, Stephan Philipp, Justyna Sosna, Charles G Glabe, Tamir Gonen, David S Eisenberg

Institutions: Howard Hughes Medical Institute, University of California, Los Angeles, University of California, Irvine, King Abdulaziz University, Janelia Research Campus

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

OpenAlex ID: W2984081504

Cites:

Cited by: 1

Related to: 10