Work

Author response: An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1

Year: 2016

Type: peer-review

Abstract: The seemingly simple, constitutive response of the patched/Ptch1 gene to Hedgehog signaling is in fact regulated by large batteries of context-specific Hedgehog-responsive enhancers in both fly and mouse, allowing tissue-specific tuning of the Hedgehog pathway in animal development and evolution.

DOI: 10.7554/elife.13550.030

Authors: David S Lorberbaum, Andrea I Ramos, Kevin A Peterson, Brandon S Carpenter, David S Parker, Sandip De, Lauren E Hillers, Victoria M Blake, Yuichi Nishi, Matthew R McFarlane, Ason CY Chiang, Judith A Kassis, Benjamin L Allen, Andrew P McMahon, Scott Barolo

Institutions: University of Michigan, Michigan Medicine, Harvard University, Jackson Laboratory, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, University of Southern California

Language: English

Topic: Hedgehog Signaling Pathway Studies

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

OpenAlex ID: W2984148571

Cites:

Cited by:

Related to: 10