Year: 2019
Type: article
Abstract: BACKGROUND: Meta-analyses confirm increased circulating C-reactive protein (CRP) levels in depression. Longitudinal studies have linked one-off measurements of CRP at baseline with increased risk of developing depressive symptoms subsequently at follow-up, but studies with repeat CRP measures from the same individuals are scarce. METHODS: We have examined whether longitudinal patterns of inflammation, based on three CRP measurements from childhood to early-adulthood, are associated with the risk of depression in early-adulthood in the Avon Longitudinal Study of Parents and Children, a prospective birth cohort. RESULTS: Using Gaussian mixture modelling of available CRP data from age 9, 15 and 18 years, we identified four population clusters/sub-groups reflecting different longitudinal patterns of CRP: persistently low (N=463, 29.5%); persistently high (N=371, 24%); decreasing (N=360, 23%); increasing (N=367, 23.5%). The increasing group showed a steep increase in CRP levels between adolescence and early-adulthood. Participants in this group had a higher risk of moderate/severe depression at age 18 years, compared with those with persistently low CRP; adjusted odds ratio (OR)=3.78 (95% Confidence Interval (CI), 1.46-9.81; p=0.006). The odds of moderate/severe depression were also increased for the persistently high CRP group, but this was not statistically significant; OR=2.54 (95% CI, 0.90-7.16). LIMITATIONS: Repeat CRP measures were available for a subset, who may not be representative of all cohort participants. CONCLUSIONS: The results suggest that an increasing pattern of inflammation from adolescence to early-adulthood is associated with risk of depression in early-adulthood.
Source: Comprehensive Psychiatry
Language: English
Subfield: Biological Psychiatry
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,100
Funders: Wellcome Trust, MQ: Transforming Mental Health, University Hospitals Bristol NHS Foundation Trust, National Institute for Health and Care Research, University of Bristol, Norges Idrettshøgskole, National Institutes of Health, Medical Research Council, National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: G1145678202, G1192034430, G1605161196, G2533062745, Genetic investigation of life course phenotypes of mental health and illness in the 1946 British birth cohort., The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi-generation, longitudinal resource, G3345452146, G3398632049, G3430465513, G3472600982, G3512615570, The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi- generation, longitudinal resource focusing on life course health and well- being., The Cambridge-UCL Mental Health and Neurosciences Network., G3831911591, G3964678366, Genetic investigation of life course phenotypes of mental health and illness in the 1946 British birth cohort, G4231014882, G4260143917, The Avon Longitudinal Study for Parents and Children: An international resource for population genomic and lifecourse epidemiology. Core programme support 2014-2019., G4643449984, The Avon Longitudinal Study of Parents and Children: An international resource for population
genomics and lifecourse epidemiology. Core Programme Support 2011-2015 and Core programme support 2014-2019, G4874266232, G5562631338, G5570099221, G5702265173, MRC Centre for Neuropsychiatric Genetics and Genomics, G5857625837, G5957846447, G6210185106, G6285500577, G6342754709, Tailoring evidence-based psychological therapY for People with common mental disorder including Psychotic EXperiences (TYPPEX), G6921627357, Inflammation and Immunity in Depression: from novel mechanisms towards therapeutics, Maternal overnutrition and offspring fat mass, metabolic and vascular function., G710448223, G7331652800, G7708287604, G7785669168, G7828794151, G8002845744, The Cambridge-UCL Mental Health and Neurosciences Network., G8256162305, MICA: Mental Health Data Pathfinder: University of Cambridge, Cambridgeshire & Peterborough NHS Foundation Trust, and Microsoft
OpenAlex ID: W2984556316