Work

Gpr110 deficiency decelerates carcinogen-induced hepatocarcinogenesis via activation of the IL-6/STAT3 pathway.

Year: 2017

Type: article

Abstract: decelerates liver fibrosis/cirrhosis progressing into tumorigenesis, due to strengthening activation of the IL-6/STAT3 pathway, leading to a weaker liver injury and fibrosis microenvironment. It is indicated that targeting Gpr110 and activating the IL-6/STAT3 pathway may be considered to be preventive methods for some cirrhosis transition.

Source: PubMed Central

Authors: Benting Ma, Junjie Zhu, Juan Tan, Yulei Mao, Lingyun Tang, Chunling Shen, Hongxing Zhang, Ying Kuang, Jian Fei, Xiao Yang, Zhugang Wang

Institutions: Shanghai Jiao Tong University, Ruijin Hospital, State Key Laboratory of Medical Genomics, Tongji University, Shanghai Pulmonary Hospital, Shanghai Model Organisms (China), State Key Laboratory of Medical Genomics

Language: English

Topic: Liver physiology and pathology

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2984761535

FWCI: 1.083

Cites: 39

Cited by: 13

Related to: 10