A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study
Year: 2019
Type: article
Study design: Observational Study
Abstract: PURPOSE: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. METHODS: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR < 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS). RESULTS: A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS. CONCLUSIONS: Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature.
Source: European Journal of Nutrition
Authors: Nikos Papadimitriou, David Muller, Piet A. van den Brandt, Milan Geybels, Chirag J. Patel, Marc J. Gunter, David S. Lopez, Timothy J. Key, Aurora Perez-Cornago, Pietro Ferrari, Paolo Vineis, Elisabete Weiderpass, Heiner Boeing, Antonio Agudo, María-José Sánchez, Kim Overvad, Tilman Kühn, Renee T. Fortner, Domenico Palli, Isabel Drake, Anders Bjartell, Carmen Santiuste, Bas H. Bueno-de-Mesquita, Vittorio Krogh, Anne Tjønneland, Dorthe Furstrand Lauritzen, Aurelio Barricarte Gurrea, José Ramón Quirós, Pär Stattin, Antonia Trichopoulou, Georgia Martimianaki, Anna Karakatsani, Elin Thysell, Ingegerd Johansson, Fulvio Ricceri, Rosario Tumino, Nerea Larrañaga, Kay Tee Khaw, Elio Riboli, Ioanna Tzoulaki, Konstantinos K. Tsilidis
Institutions: University of Ioannina, Centre international de recherche sur le cancer, Imperial College London, Maastricht University, Care and Public Health Research Institute, Harvard University, The University of Texas Medical Branch at Galveston, The University of Texas Health Science Center at Houston, University of Oxford, Italian institute for Genomic Medicine, German Institute of Human Nutrition, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Andalusian School of Public Health, Aarhus University, German Cancer Research Center, Lund University, Instituto Murciano de Investigación Biosanitaria, University Medical Center Utrecht, University of Malaya, National Institute for Public Health and the Environment, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Copenhagen, Danish Cancer Society, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Gobierno del Principado de Asturias, Uppsala University, National and Kapodistrian University of Athens, Hellenic Health Foundation, University General Hospital Attikon, Umeå University, University of Turin, Basque Government, University of Cambridge, Addenbrooke's Hospital
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,760
Funders: World Health Organization, Deutsches Krebsforschungszentrum, Centre International de Recherche sur le Cancer, Cancer Research UK, National Institute for Health and Care Research, European Commission, Bundesministerium für Bildung und Forschung, Cancerfonden, Vetenskapsrådet, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Hellenic Health Foundation, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III, European Regional Development Fund, National Institute of Allergy and Infectious Diseases, National Institute of Environmental Health Sciences
Awards: G1032970344, G104449235, G1055973116, G1192877484, G1208621354, G1274701479, G1478484880, G1559294051, G1767199718, G1788645866, G1993546569, G2027148636, G2092716656, G2149865848, G2235605558, G2336049343, G2409987178, G2455188558, G2539064604, G2561548287, G2611591051, G2742323354, G3077395769, G3084320185, G3189789075, G3216658785, G3217467674, G331404038, G3452641779, G3675143906, G375319704, G382879149, G3980646122, G4015216323, G4049848471, G4089957676, G4213141252, G4305317257, G43956866, Health of vegetarians, G4682079261, G4752739612, G4811780622, G4879533352, G4884057766, G4913827001, G5004963360, G5119219000, G5288121262, G5375816427, G5406065712, G5651954792, G569447510, G569908600, G5750710683, G5897142711, G5990830295, G6085534252, NIHR Senior Investigator Award, G6212483348, G6320156643, G6442500046, G657255654, G6594529311, G6779186093, G6960682749, G7040807446, G7306252069, G7447125227, G7600088736, G7624991799, G7646326732, Big Data Analysis of HIV Risk and Epidemiology in Sub-Saharan Africa, G7853538257, G7983476435, G8050896463, G8279237360, G8331243404, G8374761964, G8407261631, G8525262851, G8821318293, G8867963557, G8869854444, G8959392569, G8978728421, G9000332718
OpenAlex ID: W2984794449