Work

Disruption of microtubule function in cultured human cells by a cytotoxic ruthenium( ii ) polypyridyl complex

Year: 2019

Type: article

Abstract: Treatment of cultured human cell lines with a cytotoxic IC 50 dose of ∼2 μM tris(diphenylphenanthroline)ruthenium( ii ) chloride ( RPC2 ) retards or arrests microtubule motion as tracked by visualizing fluorescently-tagged microtubule plus end-tracking proteins.

Source: Chemical Science

DOI: 10.1039/c9sc05671h

Authors: Nagham Alatrash, Faiza H. Issa, Nada S. Bawazir, Savannah J. West, Kathleen E. Van Manen-Brush, Charles P. Shelor, Adam S. Dayoub, Kenneth A. Myers, Christopher Janetopoulos, Edwin A. Lewis, Frederick M. MacDonnell

Institutions: The University of Texas at Arlington, University of the Sciences, Mississippi State University

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Welch Foundation

Award: G4892340467

OpenAlex ID: W2985210665

FWCI: 1.359

Cites: 67

Cited by: 26

Related to: 10