Author response: Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates
Year: 2019
Type: peer-review
Abstract: Invertebrate TRPM2 channels have stable pores but act as chanzymes that hydrolyze their activating ligand ADP ribose (ADPR), whereas vertebrate TRPM2 channels are catalytically dead but undergo pore inactivation.
Source: eLife
Institution: Semmelweis University
Language: English
Topic: Ion Channels and Receptors
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,500
OpenAlex ID: W2985356498