Work

Author response: Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers

Year: 2017

Type: peer-review

Abstract: The cyclic neuropeptide somatostatin binds to human Aβ1-42 through an interface that critically relies on a specific tryptophan, thereby blocking the propensity of Aβ to aggregate, a critical step in the pathobiology of Alzheimer's disease.

Source: eLife

DOI: 10.7554/elife.28401.022

Authors: Hansen Wang, Lisa D Muiznieks, Punam Ghosh, Declan Williams, Michael Solarski, Andrew Fang, Alejandro Ruiz-Riquelme, Régis Pomès, Joel C Watts, Avi Chakrabartty, Holger Wille, Simon Sharpe, Gerold Schmitt-Ulms

Institutions: University of Toronto, Great Ormond Street Hospital, Hospital for Sick Children, University of Alberta

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

OpenAlex ID: W2985396362

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