Work

Challenges and opportunities for engineering assembly-line polyketide biosynthesis in Escherichia coli

Year: 2019

Type: article

Abstract: Assembly-line polyketide synthases generate natural products that have led to many live-saving drugs. The use of E. coli as a heterologous host for reconstituting these enormous and complex enzymatic machines has and will continue to be a critical strategy for understanding them. Here, we concisely summarize successful examples in exploiting E. coli for assembly-line polyketide biosynthesis as well as offer examples of new challenges in which this approach is primed to tackle.

Source: Metabolic Engineering Communications

DOI: 10.1016/j.mec.2019.e00106

Authors: Kai P. Yuet, Chaitan Khosla

Institution: Stanford University

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $1,800

Funders: National Institutes of Health, National Institute of General Medical Sciences