A low dose of AZD8055 enhances radiosensitivity of nasopharyngeal carcinoma cells by activating autophagy and apoptosis.
Year: 2019
Type: article
Abstract: and significantly induced apoptosis and autophagy in tumor tissues, Neither 5 nor 20 mg/kg/d AZD8055 induced significantly pro-apoptosis bax expressions in mouse livers and kidneys. 5 mg/kg/d produced good radiosensitivity but had little impact on body weight. We concluded that AZD8055 was a promising candidate radiosensitizer for NPC.
Source: Europe PMC (PubMed Central)
Authors: Lihong Chang, Zizhen Huang, Shuaixiang Li, Zhouzhou Yao, Hongwei Bao, Zhiyuan Wang, Xia Li, Xiaohong Chen, Jiancong Huang, Gehua Zhang
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2985539303