Investigating Tumor Heterogeneity in Mouse Models
Year: 2019
Type: review
Abstract: Cancer arises from a single cell through a series of acquired mutations and epigenetic alterations. Tumors gradually develop into a complex tissue comprised of phenotypically heterogeneous cancer cell populations, as well as noncancer cells that make up the tumor microenvironment. The phenotype, or state, of each cancer and stromal cell is influenced by a plethora of cell-intrinsic and cell-extrinsic factors. The diversity of these cellular states promotes tumor progression, enables metastasis, and poses a challenge for effective cancer treatments. Thus, the identification of strategies for the therapeutic manipulation of tumor heterogeneity would have significant clinical implications. A major barrier in the field is the difficulty in functionally investigating heterogeneity in tumors in cancer patients. Here we review how mouse models of human cancer can be leveraged to interrogate tumor heterogeneity and to help design better therapeutic strategies.
Source: Annual Review of Cancer Biology
Authors: Tuomas Tammela, Julien Sage
Institutions: Memorial Sloan Kettering Cancer Center, Stanford University
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G135385525, G2168804857, Investigating Wnt and Lgr5 signaling as regulators of lung cancer heterogeneity, G2424621651, Phenotype Heterogeneity and Dynamics in SCLC, Novel therapeutic approaches for enhancing anti-tumor immunity in SCLC, Investigating cellular heterogeneity in lung cancer, Notch signaling in small cell lung carcinoma, G7904453859, Molecular mechanisms of SCLC initiation and detection in mice and humans
OpenAlex ID: W2985641948