Work

Deoxyribonucleotide salvage falls short in whole animals

Year: 2019

Type: article

Abstract: Ribonucleotide reductase (RNR) catalyzes the first committed reaction in DNA synthesis. Most of what we know about RNR regulation comes from studies with cultured cells and with purified proteins. In this study, Tran et al. use Cre-Lox technology to inactivate RNR large subunit expression in heart and skeletal muscle of mouse embryos. Analysis of these mutants paints a picture of dNTP regulation in whole animals quite different from that seen in studies of purified proteins and cultured cells.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.h119.011335

Author: Christopher K. Mathews

Institution: Oregon State University

Language: English

Topic: Biochemical and Molecular Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

OpenAlex ID: W2985655392

FWCI: 0.165

Cites: 5

Cited by: 2

Related to: 10