Year: 2009
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: Changes in plasma thioredoxin (TRX) concentrations before, during, and after a 130-km endurance race were measured with the aim of elucidating the relationship between exercise and oxidative stress (OS). METHODS: Blood samples were taken from 18 runners participating in a 2-day-long 130-km ultra-marathon during the 2 days of the race and for 1 week thereafter. There were six sampling time points: at baseline, after the goal had been reached on the first and second day of the endurance race, respectively, and on 1, 3, and 5/6 days post-endurance race. The samples were analyzed for plasma TRX concentrations, platelet count, and blood lipid profiles. RESULTS: Concentrations of plasma TRX increased from 17.9 ± 1.2 ng/mL (mean ± standard error of the mean) at baseline to 57.3 ± 5.0 ng/mL after the first day's goal had been reached and to 70.1 ± 6.9 ng/mL after the second day's goal had been reached; it then returned to the baseline level 1 day after the race. Platelet counts of 21.3 ± 1.2 × 10(4) cell/μL at baseline increased to 23.9 ± 1.5 × 10(4) cells/μL on Day 1 and to 26.1 ± 1.0 × 10(4) cells/μL on Day 2. On Day 7, the platelet counts had fallen to 22.1 ± 1.2 × 10(4) cell/μL. There was a significant positive correlation between plasma TRX and platelet count. CONCLUSIONS: These data suggest that plasma TRX is an OS marker during physical exercise. Further studies are needed to determine the appropriate level of exercise for the promotion of health.
Authors: Mitsuhiro Marumoto, Sadao Suzuki, Akihiro Hosono, Kazuyuki Arakawa, Kiyoshi Shibata, Mizuho Fuku, Chiho Goto, Yuko Tokudome, Hideki Hoshino, Nahomi Imaeda, Masaaki Kobayashi, Junji Yodoi, Shinkan Tokudome
Institutions: Nagoya City University, Nagoya University, Kasugai Municipal Hospital, Yokohama City University Medical Center, Nagoya Bunri University, Nagoya University of Arts and Sciences, Aichi Bunkyo Women's College, Nagoya Women's University, Kyoto University, National Institute of Health and Nutrition
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,145
OpenAlex ID: W1982443559