Author response: Cyclooxygenase-2 inhibition reduces stress-induced affective pathology
Year: 2016
Type: peer-review
Abstract: People may experience a stressful or traumatic event that can cause anxiety in their day-to-day lives. For some people, this anxiety can persist and develop into a disorder, such as posttraumatic stress disorder (PTSD) or acute stress disorder. Millions of people worldwide suffer from these disorders, but there are few classes of drug treatments currently available. Some preliminary studies in mice have suggested that anti-inflammatory drugs called cyclooxygenase-2 (COX-2) inhibitors may relieve symptoms of anxiety. COX-2 inhibitors target an enzyme called cyclooxygenase-2, which is produced in many tissues throughout the body and brain. Some COX-2 inhibitors, such as Celebrex, are already widely used to treat arthritis. Studies in people have also suggested these drugs given in combination with antidepressants might also help people with depression, while a recently developed COX-2 inhibitor, called LM-4131, stops the breakdown of chemicals produced in the brain that interact with the same brain receptors that marijuana does. In animal studies, this new drug reduced anxious behaviors. However, scientists didn’t know if the drug would also reduce anxious behaviors after animals were exposed to a traumatic or stressful experience. Now, Gamble-George et al. – including some of the same scientists that created LM-4131 – show this drug does reduce anxious behavior in mice after a traumatic or stressful experience. In the experiments, mice were stressed with an electric shock to their feet and then treated with LM-4131, Celebrex, another COX-2 inhibitor sometimes used in humans, or an inactive control. The mice were then placed in new environments or mazes high off the ground that usually trigger anxious behavior. The mice treated with any of the three COX-2 inhibitors were less likely to act like they were anxious than the mice treated with the control solution. Gamble-George et al. then showed that LM-4131 changes how cells in the brain become excited in both isolated mouse brain cells and live mice. Short-term stress in humans is known to excite cells in an area of the brain called the amygdala, which controls how we respond to stress or trauma. The experiments showed that LM-4131 decreases this activity and decreases anxiety in stressed mice. Future animal and human studies are needed to confirm that COX-2 inhibitors are a useful treatment for stress disorders, and learn more about how they work.
Language: English
Subfield: Behavioral Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W2986886428