Work

Long noncoding RNA PiHL regulates p53 protein stability through GRWD1/RPL11/MDM2 axis in colorectal cancer

Year: 2019

Type: article

Abstract: Our study illustrates how cancer cells hijack the PiHL-p53 axis to promote CRC progression and chemoresistance. PiHL plays an oncogenic role in CRC carcinogenesis and is an independent prognostic factor as well as a potential therapeutic target for CRC patients.

Source: Theranostics

DOI: 10.7150/thno.36045

Authors: Xuan Deng, Sihan Li, Fanyang Kong, Haoyu Ruan, Xiao Xu, Xinju Zhang, Zhiyuan Wu, Lin Zhang, Ying Xu, Hong Yuan, Haixia Peng, Da Yang, Ming Guan

Institutions: Shanghai Medical College of Fudan University, Fudan University, Huashan Hospital, University of Pittsburgh, Second Military Medical University, Changhai Hospital, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, Shanghai Jiao Tong University, Tongren Hospital, Dalian Medical University, First Affiliated Hospital of Dalian Medical University

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

OpenAlex ID: W2987288239

FWCI: 2.489

Cites: 3

Cited by: 63

Related to: 10