Work

Author response: Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

Year: 2019

Type: peer-review

Abstract: Diverse KATP channel inhibitors occupy a common binding pocket and stabilize an interaction between Kir6.2 and SUR1 to allosterically control gating and promote the assembly and trafficking of nascent channels.

DOI: 10.7554/elife.46417.041

Authors: Gregory M Martin, Min Woo Sung, Zhongying Yang, Laura M Innes, Balamurugan Kandasamy, Larry L David, Craig Yoshioka, Show-Ling Shyng

Institution: Oregon Health & Science University

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

OpenAlex ID: W2987306905

Cites:

Cited by: 1

Related to: 10