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How to differentiate pseudoprogression from true progression in cancer patients treated with immunotherapy.

Year: 2019

Type: review

Abstract: Immunotherapy has achieved unprecedented clinical efficacy in patients with various types of advanced tumors; however, some patients experience delayed tumor shrinkage following an increase in tumor burden after such a therapeutic method. This phenomenon is called pseudoprogression and can lead to premature cessation of efficacious immunotherapeutic agents. Consequently, we summarized the available data on methods to differentiate pseudoprogression from true progression in patients who have been treated with immunotherapy including biomarkers, medical imaging techniques and biopsy. We also introduce hyperprogression and special pseudoprogression for improved evaluation of immunotherapy.

Source: PubMed

Authors: Yiming Ma, Qiwei Wang, Qian Dong, Lei Zhan, Jingdong Zhang

Institution: Liaoning Cancer Hospital & Institute

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2987596024

FWCI: 2.112

Cites: 60

Cited by: 166

Related to: 10