Work

Reviewing co-trimoxazole for HIV-exposed, uninfected infants

Year: 2019

Type: article

Abstract: Most of the 1·3 million infants born to pregnant women living with HIV annually avoid HIV acquisition through use of maternal antiretroviral therapy (ART) and infant ART prophylaxis.1 Despite their HIV-free status, children who are HIV-exposed and HIV-uninfected have an increased risk of adverse birth, developmental, and growth outcomes and increased risks of infection-related morbidity and mortality that are not fully mitigated by breastfeeding.2 In settings with a high burden of HIV, where the health-care infrastructure is overburdened and where up to one in four infants is HIV-exposed and HIV-uninfected, such as South Africa and Botswana, modelling studies3 suggest that excess mortality in HIV-exposed, HIV-uninfected infants increases overall infant mortality rates by approximately five deaths per 1000 infants.

Source: The Lancet Global Health

DOI: 10.1016/s2214-109x(19)30454-1

Authors: Helena Rabie, Amy Slogrove, Mutsa Bwakura-Dangarembizi

Institutions: Stellenbosch University, Tygerberg Hospital, University of Zimbabwe

Language: English

Topic: HIV/AIDS Research and Interventions

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,000