Work

Sick mitochondria cause telomere damage: implications for disease

Year: 2019

Type: article

Abstract: Dysfunctional mitochondria have been implicated in a variety of human pathophysiological conditions such as cancer, neurodegeneration, and aging. However, the precise role of mitochondrial-generated reactive oxygen species (ROS) in these maladies is unclear. Using a light-activated mitochondrially targeted approach, we recently reported direct evidence that damaged mitochondria produce a wave of secondary ROS, causing rapid and preferential telomere dysfunction but not gross nuclear DNA damage (Fig 1).

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2019.1678362

Authors: Namrata Kumar, Wei Qian, Bennett Van Houten

Institutions: University of Pittsburgh, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,590