β7 Integrin Inhibition Can Increase Intestinal Inflammation by Impairing Homing of CD25hiFoxP3+ Regulatory T Cells
Year: 2019
Type: article
Abstract: Background & Aims Integrin α4β7 mediates lymphocyte trafficking to the gut and gut-associated lymphoid tissues, a process critical for recruitment of effector lymphocytes from the circulation to the gut mucosa in inflammatory bowel disease (IBD) and murine models of intestinal inflammation. Antibody blockade of β7 integrins generally is efficacious in IBD; however, some patients fail to respond, and a few patients can experience exacerbations. This study examined the effects of loss of β7 integrin function in murine models of IBD. Methods In a mouse IBD model caused by lack of interleukin 10, a cytokine important in CD25 hi FoxP3 + regulatory T cell (Treg) function, genetic deletion of β7 integrin or antibody blockade of α4β7–mucosal addressin cell adhesion molecule-1 interaction paradoxically exacerbated colitis. Results Loss of β7 impaired the capacity of Tregs homing to the gut and therefore suppress intestinal inflammation in an adoptive T-cell transfer model; however, the intrinsic suppressive function of β7-deficient Tregs remained intact, indicating that the β7 deficiency selectively impacts gut homing. Deletion of β7 integrin did not worsen colitis in an acute dextran sodium sulfate model in which Treg number and function were normal. Conclusions In Integrin subunit beta ( Itgb ) 7 -/- Il10 -/- mice, loss of β7-dependent Treg homing to gut-associated lymphoid tissues combined with loss of intrinsic Treg function exacerbated intestinal inflammation. These results suggest that IBD patients with reduced CD25 hi FoxP3 + Treg numbers or function or lack of interleukin 10 could be at risk for failure of α4β7 blocking therapy.
Institution: University of California San Diego
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,000
Awards: G211751754, Regulation of endothelial gene expression by cerebral cavernous malformation complex, Deconvoluting the Vascular Adhesome, Novel Traffic-targeted Therapies for IBD, Integrin Transmembrane Signaling in Inflammation and Thrombosis, G3687871348, Cellular Mechanisms of Inflammation, Hemostasis, and Thrombosis, G9000250858, Training in Cardiovascular Physiology and Pharmacology, Mechanisms of hypoxia induced exacerbation of cerebral cavernous malformations, UCSD Future Faculty of Cardiovascular Sciences (FOCUS), San Diego Digestive Diseases Research Center
OpenAlex ID: W2988193444