Work

Chemerin stimulates aortic smooth muscle cell proliferation and migration via activation of autophagy in VSMCs of metabolic hypertension rats.

Year: 2019

Type: article

Abstract: , chemerin significantly stimulated HA-SMC proliferation and migration, as determined by MTT assay and scratch assay, respectively. Chemerin significantly increased LC3 and beclin-1 levels, as measured by western blot analysis, while this effect was inhibited by the autophagy inhibitor 3-MA. It is demonstrated that chemerin stimulates SMC proliferation and migration via autophagy, which may lead to vascular structural remodeling in metabolic hypertension.

Source: Europe PMC (PubMed Central)

Authors: Juan Wen, Jiajie Wang, Lan Guo, Weijun Cai, Yang Wu, Wei Chen, Xiaohong Tang

Institutions: Central South University, Third Xiangya Hospital, Xiangya Hospital Central South University

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2988394081

FWCI: 1.818

Cites: 24

Cited by: 31

Related to: 10