Fecal Microbial Transplantation impact on gut microbiota composition and metabolome, microbial translocation and T-lymphocyte immune activation in recurrent Clostridium difficile infection patients.
Year: 2019
Type: article
Abstract: This short communication reports the preliminary results of Fecal Microbial Transplantation (FMT) impact on microbiota, microbial translocation (MT), and immune activation in four recurrent Clostridium difficile infection (R-CDI) patients. After FMT a restore of gut microbiota composition with a significant increase of fecal acetyl-putrescine and spermidine and fecal acetate and butyrate, a decrease of immune activation of T cells CD4+ and CD8+levels, and of LPS binding protein (LBP) level, were observed. Preliminary results indicate that FMT seems to be helpful not only as a CDI radical cure, with an impact on fecal microbiota and metabolome profiles, but also on MT and immune activation.
Source: PubMed
Authors: Giovanni Bruno, Antonella Gagliardi, Alessandra Oliva, Maria Trancassini, Alberto Macone, Clelia Cicerone, Alessandra D'Abramo, Valerio Iebba, Stefania Auria, Giulia Bonfiglio, Maria Antonella Zingaropoli, Gabriella D'Ettorre, Danilo Badiali, Vincenzo Vullo, Enrico S Corazziari, Serena Schippa
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2988429539