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Author response: Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor

Year: 2017
Type: peer-review
Abstract: A detailed time-series analysis reveals that the interleukin-10 receptor prevents susceptibility to microbiota-driven colonic inflammation that emerges at the time of weaning by directly inhibiting the acquisition of a pro-inflammatory intestinal macrophage phenotype.
Source: eLife
DOI: 10.7554/elife.27652.021
Authors: Naresh S Redhu, Vasudevan Bakthavatchalu, Evan A Conaway, Dror S Shouval, Amy Tsou, Jeremy A Goettel, Amlan Biswas, Chuanwu Wang, Michael Field, Werner Muller, Andre Bleich, Ning Li, Georg K Gerber, Lynn Bry, James G Fox, Scott B Snapper, Bruce H Horwitz
Institutions: Boston Children's Hospital, Harvard University, Massachusetts Institute of Technology, Brigham and Women's Hospital, Tel Aviv University, Sheba Medical Center, Edmond and Lily Safra Children's Hospital, University of Manchester, Medizinische Hochschule Hannover
Language: English
Subfield: Genetics
Open Access status: gold
Estimated APC paid: $2,500
OpenAlex ID: W2988477661
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Related to: 10