Work

Author response: Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity

Year: 2017

Type: peer-review

Abstract: Flexibility is a defining feature of AKAP kinase-phosphatase assemblies and points toward a mechanism whereby combinatorial recruitment of binding partners tailors the overall conformation of the macromolecular assembly, allowing customized physiological roles.

DOI: 10.7554/elife.30872.022

Authors: Patrick J Nygren, Sohum Mehta, Devin K Schweppe, Lorene K Langeberg, Jennifer L Whiting, Chad R Weisbrod, James E Bruce, Jin Zhang, David Veesler, John D Scott

Institutions: Howard Hughes Medical Institute, University of Washington, University of California San Diego, Florida State University, National High Magnetic Field Laboratory

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

OpenAlex ID: W2988944836

Cites:

Cited by: 1

Related to: 10