Work

Cerebellar volume loss in radiologically isolated syndrome

Year: 2019

Type: article

Study design: Observational Study

Abstract: Radiologically isolated syndrome (RIS), in which asymptomatic demyelinating-appearing lesions are detected incidentally on MRI, can be a pre-clinical form of multiple sclerosis (MS). In this study, we measured cerebellar volumes on 3D T1-weighted 3T MR images in 21 individuals with RIS and 38 age- and sex-matched healthy controls (HC). Normalized cerebellar white matter volume and the anterior cerebellar gray matter volume were significantly decreased in RIS compared to HC ( p = 0.003 and p = 0.005, respectively). Our findings support reports of regional brain atrophy in RIS prior to the development of a seminal attack related to inflammatory demyelination.

Source: Multiple Sclerosis Journal

DOI: 10.1177/1352458519887346

Authors: Ilena C George, Mohamed Mounir El Mendili, Matilde Inglese, Christina J Azevedo, Orhun Kantarci, Christine Lebrun, Aksel Siva, Darin T Okuda, Daniel Pelletier

Institutions: Icahn School of Medicine at Mount Sinai, Ospedale Policlinico San Martino, University of Genoa, University of Southern California, Mayo Clinic, Université Côte d'Azur, Hôpital Pasteur, Istanbul University-Cerrahpaşa, Istanbul University, The University of Texas Southwestern Medical Center

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Multiple Sclerosis Society, Race to Erase MS, National Institutes of Health, National Institute of Neurological Disorders and Stroke

Awards: Molecular and Genetic Predictors of Disability Progression in MS, G3782180976, G6565602889

OpenAlex ID: W2989152631

FWCI: 2.392

Cites: 12

Cited by: 31

Related to: 10