Work

The Role of Post-Translational Modifications in the Phase Transitions of Intrinsically Disordered Proteins

Year: 2019

Type: review

Abstract: Advances in genomics and proteomics have revealed eukaryotic proteomes to be highly abundant in intrinsically disordered proteins that are susceptible to diverse post-translational modifications. Intrinsically disordered regions are critical to the liquid-liquid phase separation that facilitates specialized cellular functions. Here, we discuss how post-translational modifications of intrinsically disordered protein segments can regulate the molecular condensation of macromolecules into functional phase-separated complexes.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms20215501

Authors: Izzy Owen, Frank Shewmaker

Institution: Uniformed Services University of the Health Sciences

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $1,824

Funder: National Institute of General Medical Sciences