Work

Why not add some SPARKL to your life (and death)!?

Year: 2019

Type: article

Abstract: Quantifying cytostatic and cytotoxic outcomes of cells responding to perturbagens is an essential component of mechanism-based studies and pharmacological screening approaches. We recently described an easy and versatile method for single-cell and population-level analyses using real-time kinetic labeling (SPARKL). This technology enables zero-handling, non-disruptive protocols for integrating proliferation profiles with cell death mechanisms, along with advanced mathematics for robust analyses.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2019.1685841

Authors: Jesse D. Gelles, Jerry Edward Chipuk

Institutions: Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze