Is there a central role for the cerebral endothelium and the vasculature in the brain response to conditioning stimuli?
Year: 2018
Type: article
Abstract: A variety of conditioning stimuli (e.g. ischemia or hypoxia) can protect against stroke-induced brain injury. While most attention has focused on the effects of conditioning on parenchymal injury, there is considerable evidence that such stimuli also protect the cerebrovasculature, including the blood-brain barrier. This review summarizes the data on the cerebrovascular effects of ischemic/hypoxic pre-, per- and post-conditioning and the mechanisms involved in protection. It also addresses some important questions: Are the cerebrovascular effects of conditioning just secondary to reduced parenchymal injury? How central is endothelial conditioning to overall brain protection? For example, is endothelial conditioning sufficient or necessary for the induction of brain protection against stroke? Is the endothelium crucial as a sensor/transducer of conditioning stimuli?
Source: PubMed
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: Lipocalin-2 and Intracerebral Hemorrhage-induced Brain Injury, Claudin Expression Profiles and Blood Brain Barrier in Aging, Early hematoma lysis and hemoglobin toxicity in intracerebral hemorrhage, Perivascular astrocyte swelling after BBB disruption, Targeting CD47 to aid in clearing intracerebral hemorrhages, Iron, minocycline and brain injury after intracerebral hemorrhage, Mechanisms of Brain Injury after Intraventricular Hemorrhage
OpenAlex ID: W2989651541