Work

Quantification of magnetic nanoparticles by compensating for multiple environment changes simultaneously

Year: 2019

Type: article

Abstract: The quantification of magnetic nanoparticles is important for many applications, especially for in vivo biosensing. The magnetization harmonics used in spectroscopy of magnetic nanoparticles can be used to estimate nanoparticle number or weight. However, other effects such as temperature or relaxation time change can also influence the nanoparticle magnetization. Therefore, it is necessary to compensate for these factors when estimating the amount of magnetic nanoparticles. This paper shows through simulation that a two-dimensional scaling method can be used to improve the accuracy of nanoparticle quantification, especially when multiple effects are present which can influence the nanoparticle magnetization. Finally, an experiment was performed on a Magnetic Spectroscopy of Brownian motion (MSB) apparatus to demonstrate this method, and nanoparticle weight was determined with a mean error of 1.3 ng (1.81%).

Source: Nanoscale

DOI: 10.1039/c9nr08258a

Authors: Yipeng Shi, Dhrubo Jyoti, Scott W. Gordon-Wylie, John B. Weaver

Institutions: Dartmouth College, Dartmouth–Hitchcock Medical Center

Language: English

Topic: Characterization and Applications of Magnetic Nanoparticles

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Institute of Biomedical Imaging and Bioengineering, Center for Scientific Review

Awards: G1283241909, Novel Techology for Early Indentification of Surgical Infections