Year: 2019
Type: article
Abstract: Significance Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. CD8 + T cells have been strongly implicated in MS pathogenesis, but it is unclear whether myelin is a CD8 + T cell autoantigenic target in MS. This study demonstrated that while myelin-specific CD8 + T cells are present at similar frequencies in untreated MS patients and healthy subjects, the proportion of memory and CD20-expressing myelin-specific CD8 + T cells was increased in MS patients, suggesting prior antigen encounter. This activated phenotype was reversible as the memory and CD20-expressing populations of certain myelin-specific CD8 + T cells were reduced following anti-CD20 treatment.
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G1040515108, G1574713008, G1699890706, Detection of disease-relevant CD8+ T cells in Multiple Sclerosis, Repertoire selection of AQP4-specific T cells that cause CNS autoimmunedisease, G339107648, Single cell RNA-Seq and clonal analysis of CD8+ T cells in MS, G4020154096, BD FACSAria II Flow Cytometer, G4963622356, G6095055285, G6719322097, Disease relevance of CD20 expression on T cells in multiple sclerosis patients, Mechanisms by which effector T cells modulate endogenous remyelination
OpenAlex ID: W2989833866