Work

Vitisin B as a novel fatty acid synthase inhibitor induces human breast cancer cells apoptosis.

Year: 2019

Type: article

Abstract: Pall. var. chinensis (Fisch.), was a novel FAS inhibitor. We found that vitisin B could down-regulate FAS expression and inhibit intracellular FAS activity in MDA-MB-231 cells. Also, we reported for the first time that vitisin B exhibited apoptotic effect on human breast cancer cells. Given all of this, we proposed a hypothesis that vitisin B has an application potential in the chemoprevention and treatment of breast cancer.

Source: Europe PMC (PubMed Central)

Authors: Xiaoyan Wang, Bing Jiang, Huanhuan Lv, Yan Liang, Xiaofeng Ma

Institutions: Zhejiang Chinese Medical University, University of Chinese Academy of Sciences, Capital University of Physical Education and Sports

Language: English

Topic: Cancer, Lipids, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2989837302

FWCI: 0.075

Cites: 50

Cited by: 7

Related to: 10