Work

Inhibition of neddylation plays protective role in lipopolysaccharide-induced kidney damage through CRL-mediated NF-κB pathways.

Year: 2019

Type: article

Abstract: results show that MLN4924 protected against LPS-induced AKI at relatively low doses. Collectively, these results suggest that pharmacologically blocking neddylation by MLN4924 results in the suppression of pro-inflammatory cytokines generation through the CRL/NF-κB pathway in LPS-stimulated HK2 cells, and attenuated renal inflammation in LPS-induced AKI.

Source: PubMed

Authors: Zongjie Fu, Weitang Liao, Hongkun Ma, Zhiyu Wang, Mengdi Jiang, Xiaobei Feng, Wen Zhang

Institutions: Shanghai Jiao Tong University, Ruijin Hospital, Sun Yat-sen University, Sun Yat-sen Memorial Hospital

Language: English

Topic: Acute Kidney Injury Research

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2989855921

FWCI: 1.155

Cites: 31

Cited by: 15

Related to: 10