Work

Poor survival after resection of early gastric cancer: extremes of survivorship analysis reveal distinct genomic profile

Year: 2019

Type: article

Abstract: A subset of patients with early gastric cancer demonstrate early recurrence and poor survival despite margin-negative resection. This study used an extremes-of-survivorship approach to identify an association between TP53 hotspot mutations co-occurring with loss of heterozygosity and unexpectedly poor survival in early gastric cancer. This distinct genomic profile may be a novel biomarker of poor survival in patients with completely resected early gastric cancer, and warrants large-scale validation. Promising, validation needed.

Source: British journal of surgery

DOI: 10.1002/bjs.11443