Work

The Potential Role of Inhibitory Receptors in the Treatment of Psoriasis.

Year: 2017

Type: review

Abstract: Psoriasis is a common autoimmune disorder that affects the skin. Approximately 30% of individuals with psoriasis will develop inflammatory arthritis, often in the setting of human leukocyte antigen B27. Both forms of disease are thought to be the result of prolonged inflammation mediated by T lymphocytes, dendritic cells, and keratinocytes. While there are treatments aimed at immunomodulation, targeting T cell co-inhibitory receptors signaling pathways may provide therapeutic benefit. This review will discuss in detail four T cell co-inhibitory receptors and their potential application for the treatment of psoriasis and psoriatic arthritis.

Source: PubMed

Authors: Neha Shah, Sabina Sandigursky, Adam Mor

Language: English

Topic: Psoriasis: Treatment and Pathogenesis

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases

Award: Novel mechanisms regulating PD-1 signaling and function

OpenAlex ID: W2990024407

FWCI:

Cites: 76

Cited by: 4

Related to: 10